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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Quercetin, Oxaliplatin
Phytochemical Name Quercetin (PubChem CID: 5280343 )
Anticancer drug Name Oxaliplatin (PubChem CID: 9887053 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 978
Ref_1
Pair Name Quercetin, Oxaliplatin
Disease Info [ICD-11: 2B91] Colorectal cancer Investigative
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression CYCS hsa54205
Up-regulation Cleavage PARP1 hsa142
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
In Vivo Model To generate HCT116 xenografts in BALB/c nude mice, 3×10⁶ HCT116 cells were subcutaneously injected into the left and right flanks of each mouse.
Result These findings suggest that the depletion of intracellular glutathione by quercetin and sulforaphane could strengthen the anti-cancer efficacy of oxaliplatin.
03. Reference
No. Title Href
1 Quercetin-Induced Glutathione Depletion Sensitizes Colorectal Cancer Cells to Oxaliplatin. Foods. 2023 Apr 21;12(8):1733. doi: 10.3390/foods12081733. Click
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